John Mandile is a Managing Director at Sigma Prime Ventures who spent roughly two decades as an entrepreneur and business unit manager before joining Sigma in 1996, giving him deep operational experience that shapes his hands-on investing approach. He also serves as Founding Partner of Social Ventures.org and has been board chair of Health Leads for many years, reflecting an unusual combination of traditional venture investing and long-term commitment to health equity and social impact organizations. John Mandile is a Managing Director at Sigma Prime Ventures who spent roughly two decades as an entrepreneur and business unit manager before joining Sigma in 1996, giving him deep operational experience that shapes his hands-on investing approach. He also serves as Founding Partner of Social Ventures.org and has been board chair of Health Leads for many years, reflecting an unusual combination of traditional venture investing and long-term commitment to health equity and social impact organizations.