Updated: June 13, 2026
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Venture Capital Firm
Investment Fund
Media
SaaS

Upfront Ventures

Founded 1996 · Santa Monica, USA

Upfront Ventures is the venture capital firm focusing on early-stage technology companies.

Total investments

394

Successful exits

77

About the program

Description

Upfront Ventures is LA’s original venture firm, backing breakout companies at the earliest stages. With $2B+ AUM and over 25 years of investing, we lead early rounds in healthtech, biotech, and beyond—supporting founders from first check through scale.

Founded1996

Location

Program details

Value add

I started my career as a clinician because I wanted to help people heal — and I bring that same lens to investing. I’ve led clinical strategy at scaling startups, built partnerships across payers and providers, and lived the complexity of care delivery from the inside. I back founders building what should already exist — and roll up my sleeves to help them do it.

Investment offer

Check size$1,000,000 – $8,000,000
Can lead rounds
Yes
Lead preference
Always
Offer$2M - $5M
Details

Avg Check: $750K - $7M ·

Funding requirements

We invest in healthtech, biotech, life sciences, digital health, diagnostics, therapeutics, care delivery, value-based care, healthcare SaaS, mental health, women’s health, aging, AI/ML in healthcare, and regulated healthcare services.

Numbers

Total Investments
394
Total Exits
77